HPK1-IN-8

• CAT Number: I045330
• CAS Number: 1214561-09-7
• Molecular Formula: C19H17FN6O2S
• Molecular Weight: 412.44
• Purity: ≥95%
• Synonyms: 2-(3,7-dimethyl-5-oxo-1H-[1,2,4]triazolo[4,3-a]pyrimidin-6-yl)-N-[5-[(2-fluorophenyl)methyl]-1,3-thiazol-2-yl]acetamide
• InChI: InChI=1S/C19H17FN6O2S/c1-10-14(17(28)26-11(2)24-25-18(26)22-10)8-16(27)23-19-21-9-13(29-19)7-12-5-3-4-6-15(12)20/h3-6,9H,7-8H2,1-2H3,(H,22,25)(H,21,23,27)
• InChIKey: DKCQZXASVNYNLW-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N2C(=NNC2=N1)C)CC(=O)NC3=NC=C(S3)CC4=CC=CC=C4F

HPK1-IN-8 (Cat No.: I045330) is a potent and selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1), a negative regulator of T-cell receptor signaling. By blocking HPK1 activity, HPK1-IN-8 enhances T-cell activation, cytokine production, and anti-tumor immune responses, making it a promising immuno-oncology agent. It is used in preclinical studies to investigate immune modulation and cancer immunotherapy strategies. With its favorable selectivity profile and immune-enhancing effects, HPK1-IN-8 supports the development of novel therapies aimed at boosting immune checkpoint blockade and tumor-specific immunity.

Reference

[1]. Wang W, et al. Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay. Biochemistry. 2021 Oct 19;60(41):3114-3124.
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