For research use only. Not for therapeutic Use.
HNMPA-(AM)₃ (Cat No.:I044116) is a cell-permeable inhibitor of the insulin receptor tyrosine kinase. By targeting the ATP-binding site, it selectively blocks insulin receptor autophosphorylation and downstream signaling pathways, including PI3K/Akt. HNMPA-(AM)₃ is widely used in metabolic and diabetes research to dissect insulin-mediated cellular responses. Its AM ester groups enhance membrane permeability, making it suitable for in vitro and in vivo studies. This compound is valuable for exploring insulin resistance mechanisms, receptor-specific signaling, and evaluating potential therapeutic targets in metabolic and endocrine disorders.
| CAS Number | 120944-03-8 |
| Synonyms | [bis(acetyloxymethoxy)phosphoryl-naphthalen-2-ylmethoxy]methyl acetate |
| Molecular Formula | C20H23O10P |
| Purity | ≥95% |
| IUPAC Name | [bis(acetyloxymethoxy)phosphoryl-naphthalen-2-ylmethoxy]methyl acetate |
| InChI | InChI=1S/C20H23O10P/c1-14(21)25-11-28-20(19-9-8-17-6-4-5-7-18(17)10-19)31(24,29-12-26-15(2)22)30-13-27-16(3)23/h4-10,20H,11-13H2,1-3H3 |
| InChIKey | UQODAZKXEREJLZ-UHFFFAOYSA-N |
| SMILES | CC(=O)OCOC(C1=CC2=CC=CC=C2C=C1)P(=O)(OCOC(=O)C)OCOC(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
