HLY78

• CAT Number: I011840
• CAS Number: 854847-61-3
• Molecular Formula: C17H17NO2
• Molecular Weight: 267.328
• Purity: ≥95%
• Target: Wnt/β-catenin
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 4-ethyl-5-methyl-6H-[1,3]dioxolo[4,5-j]phenanthridine
• InChI: InChI=1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3
• InChIKey: FAZZYPIBZBGQSH-UHFFFAOYSA-N
• SMILES: CCC1=CC=CC2=C1N(CC3=CC4=C(C=C32)OCO4)C

HLY78 is a positive modulator of the Wnt/β-catenin pathway, as it augments Wnt-mediated signaling in cells at concentrations of 5 to 20 μM.  It has no significant effect alone, and it does not affect LiCl-stimulated β-catenin signaling. A biotinylated form of HLY78 binds Axin at its DIX domain, which is thought to potentiate Axin-LRP6 association.

Reference

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