HKOCl-4

• CAT Number: I045481
• CAS Number: 2031170-85-9
• Molecular Formula: C38H35Cl2NO7
• Molecular Weight: 688.59
• Purity: ≥95%
• Synonyms: ethyl 4-[9′-(3,5-dichloro-4-hydroxyphenoxy)-2′,2′,4′-trimethyl-3-oxospiro[2-benzofuran-1,6′-3,4-dihydrochromeno[3,2-g]quinoline]-1′-yl]butanoate
• InChI: InChI=1S/C38H35Cl2NO7/c1-5-45-34(42)11-8-14-41-31-19-33-28(18-25(31)21(2)20-37(41,3)4)38(26-10-7-6-9-24(26)36(44)48-38)27-13-12-22(17-32(27)47-33)46-23-15-29(39)35(43)30(40)16-23/h6-7,9-10,12-13,15-19,21,43H,5,8,11,14,20H2,1-4H3
• InChIKey: LUSCIMHITFMNOM-UHFFFAOYSA-N
• SMILES: CCOC(=O)CCCN1C2=CC3=C(C=C2C(CC1(C)C)C)C4(C5=C(O3)C=C(C=C5)OC6=CC(=C(C(=C6)Cl)O)Cl)C7=CC=CC=C7C(=O)O4

HKOCl-4 (Cat No.: I045481) is a selective fluorescent probe designed for the detection of hypochlorous acid (HOCl) in biological and environmental systems. Upon reaction with HOCl, it undergoes a specific chemical transformation that triggers a strong fluorescence signal, enabling sensitive and real-time monitoring. HKOCl-4 is applied in oxidative stress research, inflammation studies, and pathogen defense mechanism investigations, as HOCl is a reactive oxygen species generated by myeloperoxidase in immune cells. Its high selectivity, sensitivity, and bioimaging compatibility make it valuable in chemical biology and diagnostic applications.

Reference

[1]. Dan Yang, et al. Diarylether-based fluorogenic probes for detection of hypochlorous acid or hydroxyl radical. Patent US20160312033.

[2]. Xiaoyu Bai, et al. HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues.