Duocarmycin DM free base

• CAT Number: I018042
• CAS Number: 1116745-06-2
• Molecular Formula: C₂₆H₂₆ClN₃O₃
• Molecular Weight: 463.96
• Purity: ≥95%

Duocarmycin DM free base(CAT: I018042) is a derivative of the natural product duocarmycin, which belongs to the class of DNA alkylating agents. It is a potent cytotoxic compound that can bind to DNA and cause DNA damage. Duocarmycins have shown potential as antitumor agents by selectively targeting and damaging the DNA in cancer cells, leading to cell death. Duocarmycin DM-free base is a modified form of duocarmycin with improved pharmacokinetic properties and enhanced anticancer activity. Further research is ongoing to evaluate its therapeutic potential in the treatment of cancer.

Reference

[1]. Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-630.[2]. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4. [3]. Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782.