Hispolon

• CAT Number: M126992
• CAS Number: 173933-40-9
• Molecular Formula: C12H12O4
• Molecular Weight: 220.22
• Purity: ≥95%
• Synonyms: (3Z,5E)-6-(3,4-dihydroxyphenyl)-4-hydroxyhexa-3,5-dien-2-one
• InChI: InChI=1S/C12H12O4/c1-8(13)6-10(14)4-2-9-3-5-11(15)12(16)7-9/h2-7,14-16H,1H3/b4-2+,10-6-
• InChIKey: QDVIEIMMEUCFMW-QXYPORFMSA-N
• SMILES: CC(=O)C=C(C=CC1=CC(=C(C=C1)O)O)O

Hispolon (Cat No.: M126992) is a natural polyphenolic compound isolated from medicinal mushrooms such as Phellinus linteus. It exhibits a wide range of pharmacological activities, including antioxidant, anti-inflammatory, and anticancer properties. Hispolon induces apoptosis, inhibits cell proliferation, and modulates signaling pathways such as NF-κB, PI3K/Akt, and MAPK in various cancer cell types. It is also studied for its hepatoprotective and neuroprotective effects. Due to its bioactivity and low toxicity, hispolon is a promising candidate for drug development in oncology and chronic disease management.

Reference

[1]. Sarfraz A, et al. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017.

[2]. Arcella A, et al. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123.
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[3]. Huang CY, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742.
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[4]. Liao KF, et al. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497.
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