Thalidomide-5-OH

• CAT Number: I015020
• CAS Number: 64567-60-8
• Molecular Formula: C₁₃H₁₀N₂O₅
• Molecular Weight: 274.23
• Purity: ≥95%

Thalidomide-5-OH (CAT: I015020) is a derivative of thalidomide that serves as a cereblon (CRBN) ligand. It is employed in the design and synthesis of PROTACs (PROteolysis TArgeting Chimeras), a class of molecules used for targeted protein degradation. In the context of PROTACs, Thalidomide-5-OH can be linked to a ligand specific to the target protein of interest via a linker. This bifunctional molecule recruits the target protein to the CRBN E3 ubiquitin ligase complex, leading to its ubiquitination and subsequent proteasomal degradation.

Reference

[1]. Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.