HIF-PHD-IN-1

• CAT Number: I045759
• CAS Number: 1567657-46-8
• Molecular Formula: C17H12Cl2N6O3
• Molecular Weight: 419.22
• Purity: ≥95%
• Synonyms: 1-[1-[(1S)-1-(2,5-dichlorophenyl)ethyl]-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl]pyrazole-4-carboxylic acid
• InChI: InChI=1S/C17H12Cl2N6O3/c1-8(11-4-10(18)2-3-12(11)19)25-14-13(6-21-25)22-17(23-15(14)26)24-7-9(5-20-24)16(27)28/h2-8H,1H3,(H,27,28)(H,22,23,26)/t8-/m0/s1
• InChIKey: BJMKDEGQDAVFGT-QMMMGPOBSA-N
• SMILES: C[C@@H](C1=C(C=CC(=C1)Cl)Cl)N2C3=C(C=N2)N=C(NC3=O)N4C=C(C=N4)C(=O)O

HIF-PHD-IN-1（Cat No.:I045759）is a potent small-molecule inhibitor of prolyl hydroxylase domain enzymes (PHDs), which regulate the stability of hypoxia-inducible factors (HIFs). By blocking PHD activity, HIF-PHD-IN-1 prevents HIF degradation, leading to stabilization and activation of hypoxia-responsive genes involved in angiogenesis, erythropoiesis, and cellular adaptation to low oxygen. Researchers utilize this compound to study oxygen-sensing pathways and their roles in ischemia, anemia, and metabolic disorders. Its selective inhibition provides a valuable tool for probing hypoxia biology and exploring therapeutic strategies targeting oxygen-regulated signaling networks.