Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase. Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation. Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643(Item No. <span class=/itemid/>70730</span>).
| Catalog Number | R009838 |
| CAS Number | 24003-67-6 |
| Synonyms | N-(1-Oxohexyl)glycine; Caproylglycine; N-Caproylglycine; NSC 224460; n-Hexanoylglycine; |
| Molecular Formula | C8H15NO3 |
| Purity | 95% |
| Storage | -20°C |
| IUPAC Name | 2-(hexanoylamino)acetic acid |
| InChI | InChI=1S/C8H15NO3/c1-2-3-4-5-7(10)9-6-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12) |
| InChIKey | UPCKIPHSXMXJOX-UHFFFAOYSA-N |
| SMILES | CCCCCC(=O)NCC(=O)O |
