Hesperadin

• CAT Number: I003520
• CAS Number: 422513-13-1
• Molecular Formula: C₂₉H₃₂N₄O₃S
• Molecular Weight: 516.65
• Purity: ≥95%
• Target: Aurora Kinase
• Solubility: DMSO ≥101mg/mL Water <1.2mg/mL Ethanol ≥2.8mg/mL
• Storage: 3 years -20C powder
• IC50: 250 nM
• InChI: InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-
• InChIKey: GLDSKRNGVVYJAB-DQSJHHFOSA-N
• SMILES: CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5

Hesperadin (Cat.No:I003520) is a small molecule inhibitor that specifically targets Aurora B kinase, a key regulator of cell division. By inhibiting Aurora B kinase activity, hesperadin disrupts proper chromosome segregation and cytokinesis, leading to cell cycle arrest and cell death. It is commonly used in research to investigate cell division processes and as a potential anti-cancer therapeutic agent.

Reference

1:Synthesis and investigation of new Hesperadin analogues antitumor effects on HeLa cells. Shamsipour F, Hosseinzadeh S, Arab SS, Vafaei S, Farid S, Jeddi-Tehrani M, Balalaie S.J Chem Biol. 2014 May 18;7(3):85-91. doi: 10.1007/s12154-014-0111-3. eCollection 2014 Jul. PMID: 25077005 Free PMC Article2:The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Jetton N, Rothberg KG, Hubbard JG, Wise J, Li Y, Ball HL, Ruben L.Mol Microbiol. 2009 Apr;72(2):442-58. doi: 10.1111/j.1365-2958.2009.06657.x. Epub 2009 Mar 6. PMID: 19320832 Free PMC Article3:[Effect of the pharmacological agent hesperadin on breast and prostate tumor cultured cells]. Ladygina NG, Latsis RV, Yen T.Biomed Khim. 2005 Mar-Apr;51(2):170-6. Russian. PMID: 15945350 4:Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A.Mol Cell. 2005 Apr 29;18(3):379-91. PMID: 15866179 Free Article5:The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM.J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21. PMID: 12707311 Free PMC Article