Herboxidiene

• CAT Number: M092820
• CAS Number: 142861-00-5
• Molecular Formula: C25H42O6
• Molecular Weight: 438.60
• Purity: ≥95%
• Synonyms: Herboxidiene
• Storage: -20°C
• IUPAC Name: 2-[(2R,5S,6S)-6-[(2E,4E,6S)-7-[(2R,3R)-3-[(2R,3R,4R)-4-hydroxy-3-methoxypentan-2-yl]-2-methyloxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-5-methyloxan-2-yl]acetic acid
• InChI: InChI=1S/C25H42O6/c1-15(14-25(6)24(31-25)18(4)23(29-7)19(5)26)9-8-10-16(2)22-17(3)11-12-20(30-22)13-21(27)28/h8-10,15,17-20,22-24,26H,11-14H2,1-7H3,(H,27,28)/b9-8+,16-10+/t15-,17+,18-,19-,20-,22-,23-,24-,25-/m1/s1
• InChIKey: ISZXEMUWHQLLTC-LSIVYLFASA-N
• SMILES: CC1CCC(OC1C(=CC=CC(C)CC2(C(O2)C(C)C(C(C)O)OC)C)C)CC(=O)O

Herboxidiene（Cat No.:M092820）, also known as GEX1A, is a natural polyketide produced by the bacterium Streptomyces chromofuscus. It has attracted attention for its potent bioactivity, particularly as an antifungal agent and a potential anticancer compound. Herboxidiene works by inhibiting splicing factor 3B subunit 1, a critical component of the spliceosome machinery in cells. This inhibition can disrupt RNA splicing, affecting gene expression. Due to these properties, herboxidiene is studied for its potential therapeutic applications in cancer treatment, as it could target abnormal splicing processes that are common in many cancers.