Helioxanthin derivative 5-4-2

• CAT Number: I002574
• CAS Number: 203935-39-1
• Molecular Formula: C20H13NO5
• Molecular Weight: 347.32
• Purity: ≥95%
• Target: HBV
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.08 uM (EC50) [1][2]
• IUPAC Name: 10-(1,3-benzodioxol-5-yl)-8,9-dihydro-[1,3]benzodioxolo[7,6-f]isoindol-7-one
• InChI: InChI=1S/C20H13NO5/c22-20-12-5-10-2-4-15-19(26-9-24-15)18(10)17(13(12)7-21-20)11-1-3-14-16(6-11)25-8-23-14/h1-6H,7-9H2,(H,21,22)
• InChIKey: UVKXTQRJKHBAMT-UHFFFAOYSA-N
• SMILES: C1C2=C(C=C3C=CC4=C(C3=C2C5=CC6=C(C=C5)OCO6)OCO4)C(=O)N1

Helioxanthin derivative 5-4-2（Cat No.:I002574） is an analog of helio xanthin, which exhibits potent anti-hepatitis B virus (HBV) activity in vitro. It demonstrates high efficacy against HBV, with an EC50 (half-maximal effective concentration) value of 0.08 μM. This suggests its potential as an antiviral agent for the treatment of HBV infections.

Reference

[1]. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2]. Li Y, et al. Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201.