HDAC6-IN-26

• CAT Number: I040513
• CAS Number: 2991427-19-9
• Molecular Formula: C13H12N8O
• Molecular Weight: 296.29
• Purity: ≥95%
• Synonyms: 6-[(5-pyridin-2-yltetrazol-2-yl)methyl]pyridine-3-carbohydrazide
• InChI: InChI=1S/C13H12N8O/c14-17-13(22)9-4-5-10(16-7-9)8-21-19-12(18-20-21)11-3-1-2-6-15-11/h1-7H,8,14H2,(H,17,22)
• InChIKey: IWWAKCDINOGSFB-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)C2=NN(N=N2)CC3=NC=C(C=C3)C(=O)NN

HDAC6-IN-26 (CAT: I040513) is a potent and selective inhibitor of histone deacetylase 6 (HDAC6), an enzyme involved in the regulation of cytoskeletal dynamics, protein degradation, and cellular stress responses. By selectively targeting HDAC6, HDAC6-IN-26 modulates non-histone protein acetylation, including α-tubulin and HSP90, without broadly affecting histone acetylation. This makes it a valuable tool for investigating HDAC6’s role in cancer, neurodegeneration, and immune regulation. HDAC6-IN-26 is suitable for use in cellular assays and preclinical studies focused on epigenetic modulation and proteostasis. Supplied in high purity, it supports advanced research in therapeutic targeting of HDAC6-related pathways.

Reference

HDAC6-IN-26 (Compound 23) is a potent and selective inhibitor of histone deacetylase 6 (HDAC6), an enzyme involved in the regulation of cytoskeletal dynamics, protein degradation, and cellular stress responses. By selectively targeting HDAC6, HDAC6-IN-26 modulates non-histone protein acetylation, including α-tubulin and HSP90, without broadly affecting histone acetylation. This makes it a valuable tool for investigating HDAC6’s role in cancer, neurodegeneration, and immune regulation. HDAC6-IN-26 is suitable for use in cellular assays and preclinical studies focused on epigenetic modulation and proteostasis. Supplied in high purity, it supports advanced research in therapeutic targeting of HDAC6-related pathways.