HBX-41108

• CAT Number: I007192
• CAS Number: 924296-39-9
• Molecular Formula: C13H3ClN4O
• Molecular Weight: 266.644
• Purity: ≥95%
• Target: DUB
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
• InChI: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
• InChIKey: BIGPXXAUSQLTQR-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N

HBX 41108 (Cat.No:I007192) is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.

Reference

1:Nicholson B, Suresh Kumar KG. The multifaceted roles of USP7: new therapeutic opportunities. Cell Biochem Biophys. 2011 Jun;60(1-2):61-8. doi: 10.1007/s12013-011-9185-5. Review. PubMed PMID: 21468693.