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HA15

HA15

  • CAT Number: I002047
  • CAS Number: 1609402-14-3
  • Molecular Formula: C23H22N4O3S2
  • Molecular Weight: 466.58
  • Purity: ≥95%
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HA15 (Cat.No:I002047) is a small molecule inhibitor that targets the endoplasmic reticulum (ER) chaperone BiP/GRP78. It disrupts the interaction between BiP/GRP78 and unfolded proteins, leading to ER stress-induced apoptosis. HA15 has shown promising anticancer activity in preclinical studies and is being investigated as a potential therapeutic strategy for cancer treatment.

Catalog Number I002047
CAS Number 1609402-14-3
Molecular Formula

C23H22N4O3S2

Purity 95%
Target target: BiP, GRP78, HSPA5 [1]
Solubility 10 mM in DMSO
Storage Store at -20°C
IUPAC Name N-[4-[3-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]phenyl]-1,3-thiazol-2-yl]acetamide
InChI InChI=1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
InChIKey LBSMEKVVMYSTIH-UHFFFAOYSA-N
SMILES CC(=O)NC1=NC(=CS1)C2=CC(=CC=C2)NS(=O)(=O)C3=CC=CC4=C3C=CC=C4N(C)C
Reference

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<br>[1]. Cerezo M et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 Jun 13;29(6):805-19.

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