GW843682X

• CAT Number: I004488
• CAS Number: 660868-91-7
• Molecular Formula: C22H18F3N3O4S
• Molecular Weight: 477.46
• Purity: ≥95%
• Target: PLK
• Solubility: Soluble to 75 mM in DMSO and to 5 mM in ethanol
• Storage: Store at -20°C
• IC50: 2.2/9.1 nM(PLK1/3) [1]

GW843682X (CAT: I004488) is a potent and selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3). It exhibits high inhibitory activity with IC50 values of 2.2 nM for PLK1 and 9.1 nM for PLK3. Importantly, it demonstrates over 100-fold selectivity against a panel of approximately 30 other kinases, including cyclin-dependent kinase 1 (cdk1) and cyclin-dependent kinase 2 (cdk2). GW843682X holds promise as a valuable tool compound for investigating the functions and signaling pathways associated with PLK1 and PLK3, which are involved in cell cycle regulation and other cellular processes.

Reference

1:The cytotoxic effect of GW843682X on nasopharyngeal carcinoma. Hu Q, Chu Y, Hu W, Peng M, Song Q.Anticancer Agents Med Chem. 2016;16(12):1640-1645. PMID: 27198987 2:An in-vitro evaluation of the polo-like kinase inhibitor GW843682X against paediatric malignancies. Spaniol K, Boos J, Lanvers-Kaminsky C.Anticancer Drugs. 2011 Jul;22(6):531-42. doi: 10.1097/CAD.0b013e3283454526. PMID: 21637161