GW788388

• CAT Number: I003593
• CAS Number: 452342-67-5
• Molecular Formula: C₂₅H₂₃N₅O₂
• Molecular Weight: 425.48
• Purity: ≥95%
• Target: TGF-βR1(ALK5)
• Solubility: DMSO: ≥ 48 mg/mL
• Storage: 2-8°C
• IC50: 18 nM
• IUPAC Name: N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide
• InChI: InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
• InChIKey: SAGZIBJAQGBRQA-UHFFFAOYSA-N
• SMILES: C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5

GW788388 (Cat No.:I003593) is a potent and selective ALK5 inhibitor with IC50 of 18 nM, also inhibits other TGF-β type I and type II receptor kinase activities, but not BMP type II receptor.If you need, please feel free to contact us, we will reply to you within 24 hours.

Reference

1:Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. de Oliveira FL, Araújo-Jorge TC, de Souza EM, de Oliveira GM, Degrave WM, Feige JJ, Bailly S, Waghabi MC.PLoS Negl Trop Dis. 2012;6(6):e1696. doi: 10.1371/journal.pntd.0001696. Epub 2012 Jun 12. PMID: 22720109 Free PMC Article2:Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Petersen M, Thorikay M, Deckers M, van Dinther M, Grygielko ET, Gellibert F, de Gouville AC, Huet S, ten Dijke P, Laping NJ.Kidney Int. 2008 Mar;73(6):705-15. Epub 2007 Dec 12. PMID: 18075500 Free Article3:Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor. Gellibert F, de Gouville AC, Woolven J, Mathews N, Nguyen VL, Bertho-Ruault C, Patikis A, Grygielko ET, Laping NJ, Huet S.J Med Chem. 2006 Apr 6;49(7):2210-21. PMID: 16570917