GW-7647

• CAT Number: I007156
• CAS Number: 265129-71-3
• Molecular Formula: C29H46N2O3S
• Molecular Weight: 502.8
• Purity: ≥95%
• Target: PPAR
• Solubility: Soluble in DMSO
• Storage: Store at RT
• IUPAC Name: 2-[4-[2-[4-cyclohexylbutyl(cyclohexylcarbamoyl)amino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid
• InChI: InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
• InChIKey: PKNYXWMTHFMHKD-UHFFFAOYSA-N
• SMILES: O=C(NC1CCCCC1)N(CCCCC1CCCCC1)CCc1ccc(cc1)SC(C)(C)C(=O)O

GW-7647 (Cat.No:I007156) is a synthetic peroxisome proliferator-activated receptor alpha (PPARα) agonist. It has been investigated for its potential in the treatment of metabolic disorders such as dyslipidemia and insulin resistance. GW-7647 activates PPARα, leading to the regulation of lipid metabolism and improvement in glucose homeostasis. Clinical studies have shown its therapeutic potential in managing cardiovascular and metabolic diseases.

Reference

1:Strömqvist M, Olsson JA, Kärrman A, Brunström B. Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPARα) agonist GW7647 or to perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA). Comp Biochem Physiol C Toxicol Pharmacol. 2012 Jun;156(1):29-36. doi: 10.1016/j.cbpc.2012.03.004. PubMed PMID: 22465071.