GW 501516 - CAS 317318-70-0
GW501516 (Cat No.: I003133), also known as Endurobol or GSK-516, is a PPARδ receptor agonist with an EC50 value of 1.1 nM.
Catalog Number: I003133
CAS Number: 317318-70-0
PubChem Substance ID:347751601
Molecular Formula: C21H18F3NO3S2
Molecular Weight:453.5
Purity: ≥95%
Inventory:In Stock > 1kg;
* For research use only. Not for human or veterinary use.
Synonym
| Synonyms | GW501516; GW-501516; GW 501516; GW1516; GW 1516; GW-1516; GSK-516; GSK 516; GSK516; Endurobol. |
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Property
| Molecular Formula: | C21H18F3NO3S2 |
|---|---|
| Molecular Weight | 453.5 |
| Target: | PPAR |
| Solubility | 10 mM in DMSO |
| Purity | ≥95% |
| Storage | Store at -20°C |
| Overview of Clinical Research | <span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>GW501516 is p<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>eroxisome proliferator-activated receptor delta agonist. The </span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Phase-II clinical trials in Hyperlipidaemia in USA started in 2003.</span></span></span></span> |
| IC50 | 1 nM(EC50) |
Computed Descriptor
| IUPAC Name | 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid |
|---|---|
| InChI | InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27) |
| InChIKey | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| SMILES | OC(COC1=CC=C(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)C=C1C)=O |