GW-3333

• CAT Number: I007144
• CAS Number: 212609-68-2
• Molecular Formula: C22H36N4O4
• Molecular Weight: 420.554
• Purity: ≥95%
• Target: TACE Inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: (2R,3S)-3-[formyl(hydroxy)amino]-4-methyl-N-[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide
• InChI: InChI=1S/C22H36N4O4/c1-7-16(6)19(22(29)24-18-10-8-9-11-23-18)25-21(28)17(12-14(2)3)20(15(4)5)26(30)13-27/h8-11,13-17,19-20,30H,7,12H2,1-6H3,(H,25,28)(H,23,24,29)/t16-,17+,19-,20-/m0/s1
• InChIKey: SMZPWUUYPYYHIV-HNJRGHQBSA-N
• SMILES: CCC(C)C(C(=O)NC1=CC=CC=N1)NC(=O)C(CC(C)C)C(C(C)C)N(C=O)O

GW-3333 is a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. It is also an matrix metalloproteinase inhibitor. The efficacy of GW3333 suggests that dual inhibitors of TACE and matrix metalloproteinases may prove therapeutic as antiarthritics.

Reference

1:Tóth AE, Tóth A, Walter FR, Kiss L, Veszelka S, Ózsvári B, Puskás LG, Heimesaat MM, Dohgu S, Kataoka Y, Rákhely G, Deli MA. Compounds blocking methylglyoxal-induced protein modification and brain endothelial injury. Arch Med Res. 2014 Nov;45(8):753-64. doi: 10.1016/j.arcmed.2014.10.009. Epub 2014 Nov 13. PubMed PMID: 25446614.