GSK973

• CAT Number: I044616
• CAS Number: 2138473-38-6
• Molecular Formula: C23H23FN2O4
• Molecular Weight: 410.44
• Purity: ≥95%
• Synonyms: (2S,3S)-2-(fluoromethyl)-7-N-methyl-5-N-[(1R,5S)-3-oxabicyclo[3.1.0]hexan-6-yl]-3-phenyl-2,3-dihydro-1-benzofuran-5,7-dicarboxamide
• IUPAC Name: (2S,3S)-2-(fluoromethyl)-7-N-methyl-5-N-[(1S,5R)-3-oxabicyclo[3.1.0]hexan-6-yl]-3-phenyl-2,3-dihydro-1-benzofuran-5,7-dicarboxamide
• InChI: InChI=1S/C23H23FN2O4/c1-25-23(28)15-8-13(22(27)26-20-16-10-29-11-17(16)20)7-14-19(12-5-3-2-4-6-12)18(9-24)30-21(14)15/h2-8,16-20H,9-11H2,1H3,(H,25,28)(H,26,27)/t16-,17+,18-,19+,20?/m1/s1
• InChIKey: WZQLVEPIBAOOGF-SFDMMAKQSA-N
• SMILES: CNC(=O)C1=CC(=CC2=C1O[C@@H]([C@H]2C3=CC=CC=C3)CF)C(=O)NC4[C@H]5[C@@H]4COC5

GSK973（Cat No.:I044616）is a potent and selective antagonist of the Aryl Hydrocarbon Receptor (AhR), a ligand-activated transcription factor involved in xenobiotic metabolism, immune regulation, and tumor progression. By inhibiting AhR signaling, GSK973 modulates immune responses and reduces the expression of genes associated with immune suppression and cancer growth. It has demonstrated efficacy in preclinical models, particularly in enhancing antitumor immunity and reversing immune evasion. GSK973 is widely used in research focused on immuno-oncology, toxicology, and the development of novel therapies targeting the AhR pathway in inflammation and cancer.