GSK/'843 - CAS 1601496-05-2

GSK-843 (Cat No.:I012597) is a potent inhibitor of receptor-interacting protein kinase 3 (RIP3 or RIPK3). It binds to the kinase domain of RIP3 with high affinity, exhibiting an inhibitory concentration (IC50) of 8.6 nM. Furthermore, GSK-843 effectively inhibits the kinase activity of RIP3, with an IC50 of 6.5 nM. By targeting RIP3, GSK-843 holds promise in modulating programmed cell death pathways, particularly necroptosis.

Catalog Number: I012597

CAS Number: 1601496-05-2

PubChem Substance ID:355170963

Molecular Formula: C19H15N5S2

Molecular Weight:377.48

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsGSK843; GSK-843; 3-Benzothiazol-5-yl-7-(2,5-dimethyl-2H-pyrazol-3-yl)-thieno[3,2-c]pyridin-4-ylamine

Property

Molecular Formula: C19H15N5S2
Molecular Weight377.48
Purity≥95%
StorageStore at -20°C

Computed Descriptor

IUPAC Name3-(1,3-benzothiazol-5-yl)-7-(2,5-dimethylpyrazol-3-yl)thieno[3,2-c]pyridin-4-amine
InChIInChI=1S/C19H15N5S2/c1-10-5-15(24(2)23-10)12-7-21-19(20)17-13(8-25-18(12)17)11-3-4-16-14(6-11)22-9-26-16/h3-9H,1-2H3,(H2,20,21)
InChIKeyBPKSNNJTKPIZKR-UHFFFAOYSA-N
SMILESCC1=NN(C(=C1)C2=CN=C(C3=C2SC=C3C4=CC5=C(C=C4)SC=N5)N)C