GSK-843 (Cat No.:I012597) is a potent inhibitor of receptor-interacting protein kinase 3 (RIP3 or RIPK3). It binds to the kinase domain of RIP3 with high affinity, exhibiting an inhibitory concentration (IC50) of 8.6 nM. Furthermore, GSK-843 effectively inhibits the kinase activity of RIP3, with an IC50 of 6.5 nM. By targeting RIP3, GSK-843 holds promise in modulating programmed cell death pathways, particularly necroptosis.
| Catalog Number | I012597 |
| CAS Number | 1601496-05-2 |
| Synonyms | GSK843; GSK-843; 3-Benzothiazol-5-yl-7-(2,5-dimethyl-2H-pyrazol-3-yl)-thieno[3,2-c]pyridin-4-ylamine |
| Molecular Formula | C19H15N5S2 |
| Purity | 95% |
| Storage | Store at -20°C |
| IUPAC Name | 3-(1,3-benzothiazol-5-yl)-7-(2,5-dimethylpyrazol-3-yl)thieno[3,2-c]pyridin-4-amine |
| InChI | InChI=1S/C19H15N5S2/c1-10-5-15(24(2)23-10)12-7-21-19(20)17-13(8-25-18(12)17)11-3-4-16-14(6-11)22-9-26-16/h3-9H,1-2H3,(H2,20,21) |
| InChIKey | BPKSNNJTKPIZKR-UHFFFAOYSA-N |
| SMILES | CC1=NN(C(=C1)C2=CN=C(C3=C2SC=C3C4=CC5=C(C=C4)SC=N5)N)C |
