GSK778

• CAT Number: I014899
• CAS Number: 2451862-42-1
• Molecular Formula: C₃₀H₃₃N₅O₃
• Molecular Weight: 511.61
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-[2-(methoxymethyl)-1-[(1R)-1-phenylethyl]-8-[[(3S)-pyrrolidin-3-yl]methoxy]imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole
• InChI: InChI=1S/C30H33N5O3/c1-18-29(20(3)38-34-18)24-12-25-23(13-27(24)37-16-21-10-11-31-14-21)30-26(15-32-25)33-28(17-36-4)35(30)19(2)22-8-6-5-7-9-22/h5-9,12-13,15,19,21,31H,10-11,14,16-17H2,1-4H3/t19-,21+/m1/s1
• InChIKey: ZORLJXWXFABTPZ-CTNGQTDRSA-N
• SMILES: CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=N4)COC)C(C)C5=CC=CC=C5)OCC6CCNC6

GSK778（Cat No.:I014899）, also known as iBET-BD1, is a potent and selective inhibitor of the BD1 bromodomain of BET proteins. It exhibits significant inhibitory activity with IC50 values of 75 nM for BRD2 BD1, 41 nM for BRD3 BD1, 41 nM for BRD4 BD1, and 143 nM for BRDT BD1. GSK778 effectively mimics the effects of pan-BET inhibitors in cancer models, suggesting its potential as a therapeutic agent for cancer treatment.

Reference

[1]. Omer G, et, al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020 Apr 24; 368(6489): 387-394.