GSK4112

• CAT Number: I000818
• CAS Number: 1216744-19-2
• Molecular Formula: C18H21ClN2O4S
• Molecular Weight: 396.9
• Purity: ≥95%
• Target: Nuclear Receptors
• Solubility: 10 mM in DMSO
• Storage: Store at +4C
• IC50: 0.4 μM (EC50)
• InChI: InChI=1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3
• InChIKey: WYSLOKHVFKLWOU-UHFFFAOYSA-N
• SMILES: ClC(C=C1)=CC=C1CN(CC(OC(C)(C)C)=O)CC2=CC=C([N+]([O-])=O)S2

GSK4112 (Cat.No:I000818) is a potent and selective agonist of the liver X receptor (LXR). It has been investigated for its potential therapeutic applications in the treatment of metabolic disorders, including atherosclerosis and diabetes. GSK4112 activates LXRs, leading to the modulation of lipid metabolism and inflammation, making it a target for drug development in related diseases.

Reference

1:Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112. Chen H, Chu G, Zhao L, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA.Biochem Biophys Res Commun. 2012 Apr 6;420(2):374-9. doi: 10.1016/j.bbrc.2012.02.164. Epub 2012 Mar 8. PMID: 22425774 2:GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. Grant D, Yin L, Collins JL, Parks DJ, Orband-Miller LA, Wisely GB, Joshi S, Lazar MA, Willson TM, Zuercher WJ.ACS Chem Biol. 2010 Oct 15;5(10):925-32. doi: 10.1021/cb100141y. PMID: 20677822