For research use only. Not for therapeutic Use.
GSK360A (Cat No.: R054987) is a potent and selective inhibitor of hypoxia-inducible factor prolyl hydroxylase domain enzymes (HIF-PHDs), which regulate the stability of hypoxia-inducible factors (HIFs) under oxygen-rich conditions. By inhibiting HIF-PHDs, GSK360A stabilizes HIF-α subunits, enhancing transcription of genes involved in erythropoiesis, angiogenesis, and cellular adaptation to hypoxia. It is primarily studied in the context of anemia, ischemic conditions, and cancer. GSK360A is a valuable research tool for investigating oxygen-sensing pathways and developing therapies that mimic hypoxic responses for clinical benefit.
| CAS Number | 931399-19-8 |
| Synonyms | 2-[[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic acid |
| Molecular Formula | C17H17FN2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H17FN2O5/c18-10-3-4-12-11(7-10)15(23)14(16(24)19-8-13(21)22)17(25)20(12)6-5-9-1-2-9/h3-4,7,9,23H,1-2,5-6,8H2,(H,19,24)(H,21,22) |
| InChIKey | TYHRZQVUPPODPT-UHFFFAOYSA-N |
| SMILES | C1CC1CCN2C3=C(C=C(C=C3)F)C(=C(C2=O)C(=O)NCC(=O)O)O |
| Reference | [1]. Bao W, et, al. Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat. J Cardiovasc Pharmacol. 2010 Aug;56(2):147-55. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
