GSK2945 hydrochloride

• CAT Number: I046083
• Molecular Formula: C20H19Cl3N2O2S
• Molecular Weight: 457.80
• Purity: ≥95%
• Synonyms: N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine;hydrochloride
• InChI: InChI=1S/C20H18Cl2N2O2S.ClH/c1-14-10-18(22)7-4-16(14)12-23(11-15-2-5-17(21)6-3-15)13-19-8-9-20(27-19)24(25)26;/h2-10H,11-13H2,1H3;1H
• InChIKey: HRNMOPTYOFRUFF-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC(=C1)Cl)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-].Cl

GSK2945 hydrochloride（Cat No.:I046083）is a selective small-molecule inhibitor of cathepsin K, a lysosomal cysteine protease highly expressed in osteoclasts and critical for bone resorption. By blocking cathepsin K activity, GSK2945 hydrochloride reduces collagen degradation and bone matrix breakdown, making it a valuable tool in osteoporosis and skeletal disorder research. Its hydrochloride salt form improves solubility and stability for experimental use. GSK2945 hydrochloride is applied in studies of bone metabolism, arthritis, and related diseases, highlighting the therapeutic potential of targeting cathepsin K in bone health management.