GSK2838232

• CAT Number: I001707
• CAS Number: 1443460-91-0
• Molecular Formula: C48H73ClN2O6
• Molecular Weight: 809.57
• Purity: ≥95%
• Synonyms: (3β)-3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(4-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IUPAC Name: 4-[[(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-[(1R)-2-[(4-chlorophenyl)methyl-[2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-5a,5b,8,8,11a-pentamethyl-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3H-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid
• InChI: InChI=1S/C48H73ClN2O6/c1-30(2)40-34(52)26-48(37(53)29-51(25-24-50(10)11)28-31-12-14-32(49)15-13-31)23-22-46(8)33(41(40)48)16-17-36-45(7)20-19-38(57-39(54)27-43(3,4)42(55)56)44(5,6)35(45)18-21-47(36,46)9/h12-15,30,33,35-38,53H,16-29H2,1-11H3,(H,55,56)/t33-,35+,36-,37+,38+,45+,46-,47-,48+/m1/s1
• InChIKey: MEOWKUXNVNJAMY-PZFKGGKESA-N
• SMILES: CC(C)C1=C2C3CCC4C5(CCC(C(C5CCC4(C3(CCC2(CC1=O)C(CN(CCN(C)C)CC6=CC=C(C=C6)Cl)O)C)C)(C)C)OC(=O)CC(C)(C)C(=O)O)C

GSK2838232（Cat No.:I001707） is a compound described in patent WO/2013090664A1 (compound 51) and it has been reported to inhibit the activity of HIV reverse transcriptase. It demonstrates inhibitory effects across a broad range of HIV-1 isolates. Reverse transcriptase is an essential enzyme for the replication of the HIV virus, and inhibiting its activity can disrupt the viral replication cycle. GSK2838232 shows potential as a candidate for further development as an anti-HIV therapeutic agent.

Reference

[1]. Hatcher Mark Andrew, et al. Preparation of betulin derivatives for the treatment of HIV. From PCT Int. Appl. (2013), WO 2013090664 A1 20130620.