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GSK2795039

GSK2795039

  • CAT Number: I001595
  • CAS Number: 1415925-18-6
  • Molecular Formula: C23H26N6O2S
  • Molecular Weight: 450.56
  • Purity: ≥95%
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GSK2795039 (Cat No.:I001595) is an inhibitor of NADPHoxidase2 (NOX2), with a pIC50 value of 6.57 for NOX2-mediated activation of HRP/AmplexRed. GSK2795039 can inhibit the production of reactive oxygen species (ROS), the consumption of NADPH and reduce apoptosis.

Catalog Number I001595
CAS Number 1415925-18-6
Molecular Formula

C23H26N6O2S

Purity 95%
Target target:NADPH Oxidase 2
Solubility DMSO: ≥ 32 mg/mL
Storage 2-8°C
IUPAC Name 1-methyl-N-[3-(1-methyl-2,3-dihydroindol-6-yl)-1-propan-2-ylpyrrolo[2,3-b]pyridin-4-yl]pyrazole-3-sulfonamide
InChI InChI=1S/C23H26N6O2S/c1-15(2)29-14-18(17-6-5-16-8-11-27(3)20(16)13-17)22-19(7-10-24-23(22)29)26-32(30,31)21-9-12-28(4)25-21/h5-7,9-10,12-15H,8,11H2,1-4H3,(H,24,26)
InChIKey FMWVTCZKCXPKFW-UHFFFAOYSA-N
SMILES CC(C)N1C=C(C2=C(C=CN=C21)NS(=O)(=O)C3=NN(C=C3)C)C4=CC5=C(CCN5C)C=C4
Reference

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[1]. Hirano K et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal. 2015 Aug 10;23(5):358-74.</p>

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