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GSK2141795

GSK2141795

  • CAT Number: I000263
  • CAS Number: 1047634-65-0
  • Molecular Formula: C18H16Cl2F2N4O2
  • Molecular Weight: 429.25
  • Purity: ≥95%
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GSK2141795 (Cat No.:I000263), also known as GSK795, is a selective, ATP-competitive, orally active Akt inhibitor with IC50 for Akt 1/2/3 of 180 nM, 328 nM, and 38 nM. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Catalog Number I000263
CAS Number 1047634-65-0
Molecular Formula

C18H16Cl2F2N4O2

Purity 95%
Target Akt
Solubility DMSO: ≥ 36 mg/mL
Storage Store at -20°C
IC50 180/328/38 nM (Akt1/2/3)
IUPAC Name N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide
InChI InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
InChIKey AXTAPYRUEKNRBA-JTQLQIEISA-N
SMILES CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl
Reference

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<br>[1]. Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.
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