GSK-3β Inhibitor, TWS119

• CAT Number: I004259
• CAS Number: 601514-19-6
• Molecular Formula: C₁₈H₁₄N₄O₂
• Molecular Weight: 318.33
• Purity: ≥95%
• Target: GSK-3
• Solubility: DMSO ≥61mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
• Storage: 3 years -20℃ powder
• IC50: 30 nM
• IUPAC Name: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
• InChI: InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
• InChIKey: VPVLEBIVXZSOMQ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O

GSK-3β Inhibitor, TWS119 (Cat.No:I004259), is a small molecule compound that selectively inhibits the glycogen synthase kinase-3 beta (GSK-3β) enzyme. TWS119 has been widely studied for its role in promoting neural stem cell proliferation and differentiation. It has shown potential in regenerative medicine and neurodegenerative disease research, with implications for therapeutic development.

Reference

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