GRL0617

• CAT Number: I018166
• CAS Number: 1093070-16-6
• Molecular Formula: C₂₀H₂₀N₂O
• Molecular Weight: 304.39
• Purity: ≥95%
• Storage: 2–8 °C
• IUPAC Name: 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
• InChI: InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1
• InChIKey: UVERBUNNCOKGNZ-CQSZACIVSA-N
• SMILES: CC1=C(C=C(C=C1)N)C(=O)NC(C)C2=CC=CC3=CC=CC=C32

GRL0617 (Cat No.:I018166) is a potent, selective and competitive non-covalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLPro)/deubiquitinase with IC50 value is 0.6 μM and Ki value is 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in VeroE6 cells with a corresponding EC50 value of 15 microM and no associated cytotoxicity.

Reference

[1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.