<span>Griseofulvin is an insoluble (8.64 µg/mL) fungistatic antifungal.</span></br>The mechanism of action is not well described, but is currently thought to bind to tubulin and interfere with mitosis. In addition, griseofulvin is thought to inhibit synthesis of nucleic acids.
| Catalog Number | A000742 |
| CAS Number | 126-07-8 |
| Synonyms | NA |
| Molecular Formula | C17H17CIO6 |
| Purity | 95% |
| Target | Microtubule/Tubulin |
| Solubility | >10.5mg/mL in DMSO |
| Storage | 3 years -20C powder |
| InChIKey | DDUHZTYCFQRHIY-RBHXEPJQSA-N |
| Reference | <p>Rice, Louis B., and Mahmoud A. Ghannoum. /Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance./ Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.</p><p>Santra, Manas K., and Leslie Wilson. /Kinetic Suppression of Microtubule Dynamic Instability by Griseofulvin: Implications for Its Possible Use in the Treatment of Cancer./ PNAS pag. Pnas.org. 19 May 2005. Web. 22 Aug. 2012.</p></span></p> |
