Altrenogest

• CAT Number: A001052
• CAS Number: 850-52-2
• Molecular Formula: C21H26O2
• Molecular Weight: 310.43
• Purity: ≥95%
• Target: Estrogen/progestogen Receptor
• Solubility: >14.4mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/m1/s1
• InChIKey: VWAUPFMBXBWEQY-ANULTFPQSA-N
• SMILES: CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2(CC=C)O

Altrenogest, also known as allyltrenbolone or allyltrienolone, is a steroidal progestin of the 19-nortestosterone and allyltestosterone groups related to allylestrenol, norgestrienone, and trenbolone that is widely used in veterinary medicine to suppress or synchronize estrus in horses and pigs. It is available for veterinary use in both Europe (as Regumate) and the United States (as Matrix), and has been marketed as Regumate since the early 1980s.

Reference

1: Lopes TP, Bolarín A, Martínez EA, Roca J. Altrenogest treatment before weaning
improves litter size in sows. Reprod Domest Anim. 2017 Oct;52 Suppl 4:75-77. doi:
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2: Ziecik AJ, Klos J, Przygrodzka E, Milewski R, Jana B. Aberrant effects of
altrenogest and exposure to exogenous gonadotropins on follicular cysts
appearance in gilts. Theriogenology. 2017 Feb;89:250-254. doi:
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3: Wammer KH, Anderson KC, Erickson PR, Kliegman S, Moffatt ME, Berg SM, Heitzman
JA, Pflug NC, McNeill K, Martinovic-Weigelt D, Abagyan R, Cwiertny DM, Kolodziej
EP. Correction to Environmental Photochemistry of Altrenogest: Photoisomerization
to a Bioactive Product with Increased Environmental Persistence via Reversible
Photohydration. Environ Sci Technol. 2016 Sep 20;50(18):10292. doi:
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4: Crosier AE, Comizzoli P, Koester DC, Wildt DE. Circumventing the natural,
frequent oestrogen waves of the female cheetah (Acinonyx jubatus) using oral
progestin (Altrenogest). Reprod Fertil Dev. 2017 Aug;29(8):1486-1498. doi:
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5: Wammer KH, Anderson KC, Erickson PR, Kliegman S, Moffatt ME, Berg SM, Heitzman
JA, Pflug NC, McNeill K, Martinovic-Weigelt D, Abagyan R, Cwiertny DM, Kolodziej
EP. Environmental Photochemistry of Altrenogest: Photoisomerization to a
Bioactive Product with Increased Environmental Persistence via Reversible
Photohydration. Environ Sci Technol. 2016 Jul 19;50(14):7480-8. doi:
10.1021/acs.est.6b02608. Epub 2016 Jul 11. Erratum in: Environ Sci Technol. 2016
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6: McConaghy FF, Green LA, Colgan S, Morris LH. Studies of the pharmacokinetic
profile, in vivo efficacy and safety of injectable altrenogest for the
suppression of oestrus in mares. Aust Vet J. 2016 Jul;94(7):248-55. doi:
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7: Sodhi N. In this issue – July 2016: Canine distemper in dogs and ferrets in
Australia · Conjunctival myxoma in a dog · Antimicrobial resistance genes in
porcine pathogens · Farm economic impacts of bovine Johne/’s disease · Exertional
heat illness in horses · Suppression of oestrus in mares using injectable
altrenogest · Sex identification in the eastern blue-tongued lizard. Aust Vet J.
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8: Zhang D, Park JA, Kim SK, Cho SH, Cho SM, Yi H, Shim JH, Kim JS, Abd El-Aty
AM, Shin HC. Determination of residual levels of naloxone, yohimbine,
thiophanate, and altrenogest in porcine muscle using QuEChERS with liquid
chromatography and triple quadrupole mass spectrometry. J Sep Sci. 2016
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26697949.

9: Micheletti T, Brown JL, Walker SL, Cubas ZS, Furtado PV, Putman SB, de Moraes
W, de Oliveira MJ, de Oliveira CA, Moreira N. The use of altrenogest to avoid
hyperestrogenism after eCG-hCG ovulation induction in southern tigrina
(Leopardus guttulus). Theriogenology. 2015 Sep 1;84(4):575-82. doi:
10.1016/j.theriogenology.2015.04.015. Epub 2015 Apr 28. PubMed PMID: 26001599.

10: Stoops MA, West GD, Roth TL, Lung NP. Use of urinary biomarkers of ovarian
function and altrenogest supplementation to enhance captive breeding success in
the Indian rhinoceros (Rhinoceros unicornis). Zoo Biol. 2014 Mar-Apr;33(2):83-8.
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