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Granisetron HCl

Granisetron HCl

  • CAT Number: A000463
  • CAS Number: 107007-99-8
  • Molecular Formula: C18H24N4O • HCl
  • Molecular Weight: 348.9
  • Purity: ≥95%
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Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.<br>Granisetron blocks the delayed rectifier current (IK) of feline isolated ventricular myocytes with a KD of 4.3 mM. Granisetron shows an intrinsic voltage-dependence as the block increases with depolarization. Granisetron blocks from the intracellular side at a binding site located 10% across the transmembrane electrical field. Granisetron (3 mM) prolongs the action potential duration (APD) by about 30% at 0.5 Hz in feline isolated ventricular myocytes.<br>Granisetron provides a substantial benefit against cisplatin-induced emesis in the piglet, some animals being completely protected during both the acute and the delayed phases.

Catalog Number A000463
CAS Number 107007-99-8
Molecular Formula

C18H24N4O • HCl

Purity 95%
Target 5-HT Receptor
Solubility Limited solubility
Storage 3 years -20C powder
InChIKey QYZRTBKYBJRGJB-WQTKJZBYSA-N

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