Gramine

• CAT Number: R043630
• CAS Number: 87-52-5
• Molecular Formula: C11H14N2
• Molecular Weight: 174.247
• Purity: ≥95%
• Storage: 3 years -20C powder
• IUPAC Name: 1-(1H-indol-3-yl)-N,N-dimethylmethanamine
• InChI: InChI=1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3
• InChIKey: OCDGBSUVYYVKQZ-UHFFFAOYSA-N
• SMILES: CN(C)CC1=CNC2=CC=CC=C21

It is an inhibitor of acetylcholinesterase and butyrilcholinesterase.Indole alkaloid, from the plant Arundo donax, Gramineae.1-10 mg/kg on narcotized cats lower for a short period the arterial pressure. br10sup-5/sup and 10sup-4/sup g/ml cause inhibition of the intestine tonus and of pendulum contractions of isolated part of the intestine.brIt does not present any myotic activity, but it highly enhances the action of acetylcholine on the leech dorsal muscle and the frog ventral muscle.brIn vitro, it inhibits acetylcholinesterase and butyrilcholinesterase. At 1/5,700 concentration, it lowers the brain and blood serum cholinesterase activity by 61 %.

Reference

– Oreckov et al. Journal Organitcheskoy Khimii. (1937) (Russian). 7:63- Oubaydoullayef et al. Chem. Nat. Comp. (1976). 553- Sadritinov et al., /Pharmacology of vegetal alkaloids and their use in medecin./ Meditsina (Tashkent), (1980) (Russian).