For research use only. Not for therapeutic Use.
GR-73632（Cat No.:R036426）is a synthetic tachykinin peptide analog that acts as a selective agonist of the neurokinin-1 (NK1) receptor. By mimicking substance P activity, it is widely used to study NK1-mediated signaling pathways involved in pain perception, inflammation, smooth muscle contraction, and neurogenic responses. GR-73632 has been applied in neuroscience, gastrointestinal, and cardiovascular research to elucidate receptor function, neurotransmission, and pharmacological modulation of tachykinin pathways. Its specificity for NK1 makes it a valuable tool in evaluating therapeutic strategies targeting pain, emesis, and inflammatory diseases associated with substance P activity.
| CAS Number | 133156-06-6 |
| Synonyms | (2S)-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S)-2-[[(2S)-2-(5-aminopentanoylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]-N-methylpyrrolidine-2-carboxamide |
| Molecular Formula | C40H59N7O6S |
| Purity | ≥95% |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S)-2-[[(2S)-2-(5-aminopentanoylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]-N-methylpyrrolidine-2-carboxamide |
| InChI | InChI=1S/C40H59N7O6S/c1-27(2)24-34(38(51)44-30(36(42)49)20-23-54-4)46(3)40(53)33-18-13-22-47(33)39(52)32(26-29-16-9-6-10-17-29)45-37(50)31(25-28-14-7-5-8-15-28)43-35(48)19-11-12-21-41/h5-10,14-17,27,30-34H,11-13,18-26,41H2,1-4H3,(H2,42,49)(H,43,48)(H,44,51)(H,45,50)/t30-,31-,32-,33-,34-/m0/s1 |
| InChIKey | HQKPTSSZOJLFBZ-LJADHVKFSA-N |
| SMILES | CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CCCCN |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
