For research use only. Not for therapeutic Use.
GNE-9815（Cat No.:I045217）is a potent, selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a serine/threonine kinase implicated in Parkinson’s disease pathogenesis. By blocking LRRK2 activity, GNE-9815 modulates phosphorylation of downstream substrates, potentially restoring normal vesicular trafficking, mitochondrial function, and neuronal survival. It exhibits high potency, brain penetration, and favorable pharmacokinetics, making it suitable for central nervous system research. GNE-9815 is a valuable tool for studying LRRK2 signaling, neurodegeneration, and Parkinson’s disease mechanisms, with therapeutic potential for developing disease-modifying treatments targeting LRRK2-driven neuronal dysfunction and degeneration.
| CAS Number | 2729996-45-4 |
| Synonyms | 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxopyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide |
| Molecular Formula | C26H22FN5O2 |
| Purity | ≥95% |
| IUPAC Name | 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxopyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide |
| InChI | InChI=1S/C26H22FN5O2/c1-15-8-21(27)22(31-24(33)16-6-5-7-19(10-16)26(2,3)14-28)11-20(15)17-9-18-13-30-32(4)25(34)23(18)29-12-17/h5-13H,1-4H3,(H,31,33) |
| InChIKey | SXCTZLXYGLXXRY-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1C2=CN=C3C(=C2)C=NN(C3=O)C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
