BA-53038B

• CAT Number: I019070
• CAS Number: 2306195-65-1
• Molecular Formula: C₁₄H₁₆ClNO
• Molecular Weight: 249.74
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-(3-chlorophenyl)bicyclo[4.1.0]heptane-7-carboxamide
• InChI: InChI=1S/C14H16ClNO/c15-9-4-3-5-10(8-9)16-14(17)13-11-6-1-2-7-12(11)13/h3-5,8,11-13H,1-2,6-7H2,(H,16,17)
• InChIKey: ZLCICHYECNOTGG-UHFFFAOYSA-N
• SMILES: C1CCC2C(C1)C2C(=O)NC3=CC(=CC=C3)Cl

BA-53038B（Cat No.:I019070） is a compound categorized as an HBV core protein allosteric modulator (CpAM) that targets the HAP pocket, influencing the assembly of HBV capsids uniquely. It exhibits an EC50 value of 3.32 μM, indicating its potency in modulating the HBV capsid assembly process. By binding to the HAP pocket, BA-53038B alters the conformation and function of the HBV core protein, potentially disrupting the viral life cycle and offering a novel approach for the treatment of hepatitis B virus (HBV) infections.

Reference

[1]. Zhang X, et al. Discovery of Novel Hepatitis B Virus Nucleocapsid Assembly Inhibitors. ACS Infect Dis. 2019 May 10;5(5):759-768.