For research use only. Not for therapeutic Use.
GNE-235(CAT: I040303) is a selective small-molecule ligand targeting the second bromodomain (BD2) of PBRM1 (Polybromo-1), a subunit of the PBAF chromatin remodeling complex. With a dissociation constant of 0.28 ± 0.02 μM, GNE-235 demonstrates high affinity and specificity for PBRM1 BD2, enabling precise interrogation of its biological function. PBRM1 is implicated in chromatin regulation, tumor suppression, and transcriptional control. GNE-235 serves as a valuable chemical probe for dissecting PBRM1’s role in gene expression, cancer progression, and epigenetic signaling. It is ideal for in vitro and cell-based studies.
| Synonyms | 6-(furan-2-yl)-4-[(2S)-2-methylpyrrolidin-1-yl]pyridazin-3-amine |
| Molecular Formula | C13H16N4O |
| Purity | ≥95% |
| IUPAC Name | 6-(furan-2-yl)-4-[(2S)-2-methylpyrrolidin-1-yl]pyridazin-3-amine |
| InChI | InChI=1S/C13H16N4O/c1-9-4-2-6-17(9)11-8-10(15-16-13(11)14)12-5-3-7-18-12/h3,5,7-9H,2,4,6H2,1H3,(H2,14,16)/t9-/m0/s1 |
| InChIKey | HDGYSKKTWNREMX-VIFPVBQESA-N |
| SMILES | CC1CCCN1C2=CC(=NN=C2N)C3=CC=CO3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
