GLP-1(28-36)amide

• CAT Number: I044240
• CAS Number: 1225021-13-5
• Molecular Formula: C54H85N15O9
• Molecular Weight: 1088.35
• Purity: ≥95%
• Synonyms: (2S)-6-amino-N-[2-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]hexanamide
• InChI: InChI=1S/C54H85N15O9/c1-8-32(6)45(69-48(73)37(56)26-34-17-10-9-11-18-34)53(78)63-33(7)47(72)66-42(27-35-28-61-38-20-13-12-19-36(35)38)50(75)67-41(25-30(2)3)51(76)68-44(31(4)5)52(77)65-40(21-14-15-23-55)49(74)62-29-43(70)64-39(46(57)71)22-16-24-60-54(58)59/h9-13,17-20,28,30-33,37,39-42,44-45,61H,8,14-16,21-27,29,55-56H2,1-7H3,(H2,57,71)(H,62,74)(H,63,78)(H,64,70)(H,65,77)(H,66,72)(H,67,75)(H,68,76)(H,69,73)(H4,58,59,60)/t32-,33-,37-,39-,40-,41-,42-,44-,45-/m0/s1
• InChIKey: AYAZRBWYYBZITR-MJCVNZGZSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)N

GLP-1(28–36)amide（Cat No.:I044240）is a nonapeptide fragment derived from the C-terminal region of glucagon-like peptide-1 (GLP-1), spanning amino acids 28 to 36 and terminating with an amide group. Unlike full-length GLP-1, this fragment exerts effects independently of the classical GLP-1 receptor. It has demonstrated antioxidant, cytoprotective, and cardiometabolic benefits, including reduction of oxidative stress, improvement of mitochondrial function, and protection of cardiac and pancreatic cells. GLP-1(28–36)amide is a promising candidate in metabolic and cardiovascular research, offering a novel mechanism of action for peptide-based therapeutic development beyond traditional incretin pathways.