Globomycin

• CAT Number: I016736
• CAS Number: 67076-74-8
• Molecular Formula: C₃₂H₅₇N₅O₉
• Molecular Weight: 655.82
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 12-butan-2-yl-19-hexyl-6-(1-hydroxyethyl)-9-(hydroxymethyl)-16,18-dimethyl-15-(2-methylpropyl)-1-oxa-4,7,10,13,16-pentazacyclononadecane-2,5,8,11,14,17-hexone
• InChI: InChI=1S/C32H57N5O9/c1-9-11-12-13-14-24-20(6)32(45)37(8)23(15-18(3)4)29(42)35-26(19(5)10-2)31(44)34-22(17-38)28(41)36-27(21(7)39)30(43)33-16-25(40)46-24/h18-24,26-27,38-39H,9-17H2,1-8H3,(H,33,43)(H,34,44)(H,35,42)(H,36,41)
• InChIKey: VFGBXFZXJAWPOE-UHFFFAOYSA-N
• SMILES: CCCCCCC1C(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)O1)C(C)O)CO)C(C)CC)CC(C)C)C)C

Globomycin（Cat No.:I016736） is a lipopeptide antibiotic that acts as an inhibitor of signal peptidase II (LspA). By binding irreversibly to peptidases, globomycin prevents the processing of pro-lipoproteins. It exhibits toxicity against Spiroplasma melliferous, with minimal inhibitory concentrations (MICs) ranging from 6.25 to 12.5 μM. Through its inhibition of LspA, globomycin interferes with the proper maturation of bacterial proteins and shows potential as an antimicrobial agent targeting bacterial signal peptide processing pathways.

Reference

[1]. Béven L, et al. Inhibition of spiralin processing by the lipopeptide antibiotic globomycin. Curr Microbiol. 1996 Nov;33(5):317-22.[2]. Parthasarathy S, et al. Organophosphate Hydrolase Is a Lipoprotein and Interacts with Pi-specific Transport System to Facilitate Growth of Brevundimonas diminuta Using OP Insecticide as Source of Phosphate. J Biol Chem. 2016 Apr 1;291(14):7774-85.