Glaucocalyxin A

• CAT Number: I017708
• CAS Number: 79498-31-0
• Molecular Formula: C₂₀H₂₈O₄
• Molecular Weight: 332.43
• Purity: ≥95%

Glaucocalyxin A (CAT: I017708) is a natural diterpenoid compound isolated from the Chinese herb Rabdosia japonica. It possesses various pharmacological activities and has shown potential as an anticancer agent. Glaucocalyxin A exhibits cytotoxic effects against a wide range of cancer cell lines, including lung, breast, prostate, and colon cancers. It induces cell cycle arrest and apoptosis by regulating multiple signaling pathways, including the PI3K/AKT/mTOR, NF-κB, and MAPK pathways. Glaucocalyxin A also displays anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines. Furthermore, it exhibits anti-angiogenic activity by suppressing the formation of new blood vessels. These diverse biological activities make Glaucocalyxin A an interesting compound for further investigation as a potential therapeutic agent in cancer treatment and other diseases.

Reference

[1]. Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9(6):708.