Givinostat

• CAT Number: I003748
• CAS Number: 497833-27-9
• Molecular Formula: C24H27N3O4
• Molecular Weight: 421.49
• Purity: ≥95%
• Target: HDAC
• Solubility: ≥95 mg/mL in DMSO, ≥2 mg/mL in H2O
• Storage: 0 - 4℃
• IC50: 10 nM (for HD2), 7.5 nM (for HD1-B), 16 nM (for HD1-A) [2]

Givinostat (Cat. No: I003748) is a HDAC inhibitor that effectively inhibits total LPS-induced IL-1β production. Can be used as a reference substance for laboratory research and development and chemical pharmaceutical synthesis process.

Reference

[1]. Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-8339.

[2]. Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.