Ginsenoside Rb1

• CAT Number: I003511
• CAS Number: 41753-43-9
• Molecular Formula: C54H92O23
• Molecular Weight: 1109.3
• Purity: 98%
• Solubility: 10 mg/ml in DMSO
• Storage: -20°C
• IUPAC Name: (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• InChI: InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1
• InChIKey: GZYPWOGIYAIIPV-JBDTYSNRSA-N
• SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C

Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
IC50 value:
Target:
in vitro: Rb1 inhibited melanogenesis in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 cells in a dose-dependent manner, which collectively indicated that Rb1 may have skin-whitening effects and may be formulated into skin-whitening products for skin care [1].
in vivo: Application of 0.56mg of ginsenoside Rb1 resulted in significant decrement of scar elevation index, in comparison with control and lower dosage groups, furthermore achieved broader and randomly arranged collagen fibers resembling findings in normal dermis. Ginsenoside Rb1 concentration inversely correlated with the mRNA expression and immunohistochemical reactivity of scar related factors; MMP2, TIMP1, α-SMA, and TGF-β1 [2]. ginsenoside Rb1 treatment significantly attenuated this decrease and protected the integrity of and reduced the apoptotic rate in spinal cord neurons [3]. Ginsenoside Rb1 treatment significantly ameliorated the LPS-induced lung injury, as judged by the marked improvement in all these indices [4].

Reference

1:Involvement of serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like effect of ginsenoside Rb1, a major active ingredient of Panax ginseng C.A. Meyer. Wang GL, He ZM, Zhu HY, Gao YG, Zhao Y, Yang H, Zhang LX.J Ethnopharmacol. 2017 May 23;204:118-124. doi: 10.1016/j.jep.2017.04.009. Epub 2017 Apr 13. PMID: 28412215
2:Ginsenoside Rb1 increases insulin sensitivity through suppressing 11β-hydroxysteroid dehydrogenase type I. Song B, Ding L, Zhang H, Chu Y, Chang Z, Yu Y, Guo D, Zhang S, Liu X.Am J Transl Res. 2017 Mar 15;9(3):1049-1057. eCollection 2017. PMID: 28386332 Free PMC Article
3:Ginsenoside Rb1 improves cardiac function and remodeling in heart failure. Zheng X, Wang S, Zou X, Jing Y, Yang R, Li S, Wang F.Exp Anim. 2017 Mar 30. doi: 10.1538/expanim.16-0121. [Epub ahead of print] PMID: 28367863 Free Article
4:Ginsenoside Rb1 protects against ischemia/reperfusion-induced myocardial injury via energy metabolism regulation mediated by RhoA signaling pathway. Cui YC, Pan CS, Yan L, Li L, Hu BH, Chang X, Liu YY, Fan JY, Sun K, -Li Q, Han JY.Sci Rep. 2017 Mar 22;7:44579. doi: 10.1038/srep44579. PMID: 28327605 Free PMC Article
5:Microbial transformation of ginsenoside Rb1, Re and Rg1 and its contribution to the improved anti-inflammatory activity of ginseng. Yu S, Zhou X, Li F, Xu C, Zheng F, Li J, Zhao H, Dai Y, Liu S, Feng Y.Sci Rep. 2017 Dec;7(1):138. doi: 10.1038/s41598-017-00262-0. Epub 2017 Mar 10. PMID: 28273939 Free PMC Article
6:Biotransformation of ginsenoside Rb1 to ginsenoside Rg3 by endophytic bacterium Burkholderia sp. GE 17-7 isolated from Panax ginseng. Fu Y, Yin ZH, Yin CY.J Appl Microbiol. 2017 Jun;122(6):1579-1585. doi: 10.1111/jam.13435. Epub 2017 May 3. PMID: 28256039
7:Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum. Guo S, Chen Y, Pang C, Wang X, Qi J, Mo L, Zhang H, An H, Zhan Y.Pflugers Arch. 2017 Jan 25. doi: 10.1007/s00424-017-1934-x. [Epub ahead of print] PMID: 28124133
8:Effects of Panax notoginseng ginsenoside Rb1 on abnormal hippocampal microenvironment in rats. Wang S, Li M, Guo Y, Li C, Wu L, Zhou XF, Luo Y, An D, Li S, Luo H, Pu L.J Ethnopharmacol. 2017 Apr 18;202:138-146. doi: 10.1016/j.jep.2017.01.005. Epub 2017 Jan 5. PMID: 28065779
9:Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study. Xu X, Lu Q, Wu J, Li Y, Sun J.Inflammopharmacology. 2017 Feb;25(1):33-40. doi: 10.1007/s10787-016-0296-x. Epub 2016 Nov 17. PMID: 27853891
10:Ginsenoside-Rb1 ameliorates lithium-induced nephrotoxicity and neurotoxicity: Differential regulation of COX-2/PGE2 pathway. El-Sheikh AA, Kamel MY.Biomed Pharmacother. 2016 Dec;84:1873-1884. doi: 10.1016/j.biopha.2016.10.106. Epub 2016 Nov 12. PMID: 27847198