Ginkgetin

• CAT Number: I003693
• CAS Number: 481-46-9
• Molecular Formula: C32H22O10
• Molecular Weight: 566.51
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder

Ginkgetin (CAT: I003693) is a natural flavonoid compound derived from Ginkgo biloba leaves. It possesses various pharmacological activities and has been studied for its potential therapeutic applications. Ginkgetin exhibits antioxidant properties, helping to reduce oxidative stress and protect cells from damage. It also shows anti-inflammatory effects by inhibiting the production of pro-inflammatory molecules. Additionally, ginkgetin has been investigated for its anticancer activity, demonstrating the ability to inhibit cancer cell proliferation, induce apoptosis, and inhibit tumor growth in preclinical studies. Furthermore, ginkgetin has been explored for its neuroprotective effects and potential benefits in the treatment of neurodegenerative disorders.

Reference

[1]. Son JK, et al. Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Biol Pharm Bull. 2005 Dec;28(12):2181-4.

[2]. Jeon YJ, et al. Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of STAT3 activity. Cancer Sci. 2015 Jan 22. doi: 10.1111/cas.12608.

[3]. You OH, et al. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorg Med Chem Lett. 2013 May 1;23(9):2692-5.

[4]. Kwak WJ, et al. Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation. Planta Med. 2002 Apr;68(4):316-21.