GGTI298

• CAT Number: I002352
• CAS Number: 180977-44-0
• Molecular Formula: C27H33N3O3S
• Molecular Weight: 479.63
• Purity: ≥95%
• Synonyms: GGTI 298; GGTI-298.
• Target: Rap1a
• Solubility: Soluble to 25 mM in DMSO
• Storage: Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
• IC50: 3 μM against processing of Rap 1A
• IUPAC Name: methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate
• InChI: InChI=1S/C27H33N3O3S/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31)/t19-,25+/m1/s1
• InChIKey: XVWPFYDMUFBHBF-CLOONOSVSA-N
• SMILES: CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC3=CC=CC=C32

GGTI298 (Cat.No:I002352) is a selective inhibitor that targets geranylgeranyltransferase type I (GGTase-I), an enzyme involved in protein prenylation. By blocking the prenylation process, GGTI298 disrupts the function of small GTPases, leading to the inhibition of various signaling pathways. This compound has shown potential in cancer research and as a therapeutic agent for diseases related to abnormal protein prenylation.

Reference

[1]. Sheikh IA, et al. The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea. J Biol Chem. 2013 Jul 12;288(28):20404-15. 


[2]. Chen S, et al. Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis. Mol Cancer. 2010 Jan 29;9:23.