GGTI-2418

• CAT Number: I019142
• CAS Number: 501010-06-6
• Molecular Formula: C₂₃H₃₁N₅O₄
• Molecular Weight: 441.52
• Purity: ≥95%
• IUPAC Name: (2S)-2-[[(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxopiperazine-1-carbonyl]amino]-4-methylpentanoic acid
• InChI: InChI=1S/C23H31N5O4/c1-15(2)11-18(22(30)31)26-23(32)28-10-9-27(13-19-16(3)24-14-25-19)21(29)20(28)12-17-7-5-4-6-8-17/h4-8,14-15,18,20H,9-13H2,1-3H3,(H,24,25)(H,26,32)(H,30,31)/t18-,20-/m0/s1
• InChIKey: COLCNDRDBCLVOC-ICSRJNTNSA-N
• SMILES: CC1=C(N=CN1)CN2CCN([C@H](C2=O)CC3=CC=CC=C3)C(=O)N[C@@H](CC(C)C)C(=O)O

GGTI-2418 (Cat.No:I019142) is a small molecule inhibitor that targets the enzyme geranylgeranyltransferase I (GGTase I). GGTI-2418 has shown promise in preclinical studies for its potential anticancer properties by inhibiting the post-translational modification of signaling proteins. This inhibition disrupts cell signaling pathways involved in tumor growth and metastasis, making GGTI-2418 a potential candidate for cancer therapy.

Reference

[1]. Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63.[2]. Kuchay S, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017 Jun 22;546(7659):554-558.