For research use only. Not for therapeutic Use.
Gemcitabine triphosphate (trisodium)(CAT: I040209) is an active nucleoside metabolite of Gemcitabine (HY-17026), formed intracellularly alongside its diphosphate counterpart (dFdCDP). As the triphosphate form (dFdCTP), it is incorporated into DNA, disrupting replication and contributing to Gemcitabine’s cytotoxic effects. It serves as a critical standard in radiolabeled probe imaging to assess tumor responsiveness to Gemcitabine and to study cellular uptake, retention, and metabolic processing. This compound is valuable in pharmacokinetic and pharmacodynamic research, enabling precise evaluation of Gemcitabine’s mechanism of action, especially in cancer models exploring nucleotide metabolism, drug resistance, and DNA-targeted chemotherapeutic strategies.
| Synonyms | trisodium;[[[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate |
| Molecular Formula | C9H11F2N3Na3O13P3 |
| Purity | ≥95% |
| IUPAC Name | trisodium;[[[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate |
| InChI | InChI=1S/C9H14F2N3O13P3.3Na/c10-9(11)6(15)4(25-7(9)14-2-1-5(12)13-8(14)16)3-24-29(20,21)27-30(22,23)26-28(17,18)19;;;/h1-2,4,6-7,15H,3H2,(H,20,21)(H,22,23)(H2,12,13,16)(H2,17,18,19);;;/q;3*+1/p-3/t4-,6+,7-;;;/m1.../s1 |
| InChIKey | LTDQUZISEQVYMI-OWLHOBMCSA-K |
| SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O)(F)F.[Na+].[Na+].[Na+] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
