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GDC-0927

GDC-0927

  • CAT Number: I020261
  • CAS Number: 1642297-01-5
  • Molecular Formula: C₂₈H₂₈FNO₄
  • Molecular Weight: 461.52
  • Purity: ≥95%
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GDC-0927(CAT: I020261), also known as SRN-927, stands as a significant compound in the realm of pharmaceutical and medicinal chemistry. Serving as a potent and selective estrogen receptor antagonist, GDC-0927 offers potential applications in hormone-related conditions and cancer therapy. Its non-steroidal nature and oral bioavailability enhance its suitability for clinical use, allowing for convenient administration. By targeting estrogen receptors, GDC-0927 may hold promise in modulating estrogen signaling pathways and addressing hormone-driven diseases, including hormone-receptor-positive breast cancer.

Catalog Number I020261
CAS Number 1642297-01-5
Molecular Formula

C₂₈H₂₈FNO₄

Purity 95%
Reference

[1]. MN Dickler, et al. Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC). AACR; Cancer Res 2018;78(4 Suppl):Abstract nr PD5-10.

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