GDC-0623 - CAS 1168091-68-6

GDC-0623（Cat No.:I000603）, also known as G-868, is a highly potent inhibitor of MEK1, a key kinase in the mitogen-activated protein kinase (MAPK) signaling pathway. It acts as an ATP-noncompetitive inhibitor, meaning it does not directly compete with ATP for binding to MEK1. GDC-0623 exhibits exceptional affinity for MEK1, with a Ki value of 0.13 nM. By selectively targeting and inhibiting MEK1, GDC-0623 has the potential to disrupt aberrant MAPK signaling in cancer cells, making it a promising candidate for the development of targeted cancer therapies.

Catalog Number: I000603

CAS Number: 1168091-68-6

PubChem Substance ID:355039320

Molecular Formula: C₁₆H₁₄FIN₄O₃

Molecular Weight:456.21

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide

Property

• Molecular Formula: C₁₆H₁₄FIN₄O₃
• Molecular Weight: 456.21
• Target: MEK1/2
• Solubility: DMSO: ≥ 30 mg/mL
• Purity: ≥95%
• Storage: Store at -20°C
• IC50: 0.13 nM (Ki, +ATP); 7 nM (EC50, A375 BRAF(V600E) )

Computed Descriptor

• IUPAC Name: 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
• InChI: InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
• InChIKey: RFWVETIZUQEJEF-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCO